What specific sequencing methodology did Frederick Sanger develop in 1977?

Answer

The chain-termination method

Frederick Sanger's work in 1977 marked a monumental step forward in molecular biology by introducing the chain-termination method. This technique was foundational because it provided a reliable, albeit slow by modern standards, chemical and enzymatic approach to accurately determine the specific order of nucleotide bases within a DNA strand. This achievement represented the first generation of effective sequencing technology and was instrumental in enabling the later sequencing of viral genomes and, eventually, the first complete human genomes. While subsequent technologies dramatically increased speed and reduced cost, Sanger's method established the essential proof-of-concept for reading the genetic code.

What specific sequencing methodology did Frederick Sanger develop in 1977?

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