What was the primary function of DXplain developed at Massachusetts General Hospital (MGH) in the 1980s?
To help clinicians generate a differential diagnosis based on patient symptoms and findings
The development of DXplain at Massachusetts General Hospital (MGH) during the 1980s represented a significant geographical and functional expansion of CDSS technology beyond pure academic AI labs. While earlier systems like MYCIN focused on confirming a likely diagnosis within a narrow field, DXplain was explicitly designed as a tool to aid clinicians in the initial diagnostic reasoning process. Its core capability was generating a differential diagnosis—a list of potential conditions—using patient-provided symptoms and objective findings as input. This signaled a shift toward practical clinical support tools being developed within major hospital settings rather than solely within specialized research departments.
