What specific physical stability issues does Turbiscan track using optical techniques?
Answer
Creaming, sedimentation, and flocculation.
Turbiscan represents an advanced monitoring tool designed to track the physical stability of liquid formulations, such as suspensions and emulsions, in-situ without disrupting the container. It employs optical techniques, specifically backscattering and transmission measurements, to detect subtle structural changes occurring internally. These measurements allow researchers to directly observe and quantify physical degradation phenomena like creaming (where lighter particles rise), sedimentation (where heavier particles settle at the bottom), and flocculation (the clumping together of dispersed particles), which can render a product unusable even if chemical potency remains high.
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