Who wrote the seminal book *Compliance with Therapeutic Regimens* around the 1970s?

Sackett & Haynes

The formal, scientific study of tracking and improving patient adherence began taking substantial shape during the 1970s, particularly with foundational work emerging from McMaster University Medical Centre. Central to this early formalization was the publication of the book titled *Compliance with Therapeutic Regimens*. The authors responsible for this seminal work were Sackett and Haynes. This publication was instrumental because it helped establish 'Patient compliance' as a phenomenon that could be systematically studied, measured, and targeted for intervention. The concepts introduced helped solidify the focus in the medical community that patient adherence was a measurable component of treatment success, leading directly to its recognition as a MeSH term shortly thereafter in 1975.