What non-genetic surveillance method adapts oncology analysis for viral DNA fragments?

Answer

Applying next-generation analysis to cell-free DNA (cfDNA)

A distinct parallel path in variant tracking involved monitoring the population effects of variants rather than exclusively analyzing their genetic code via sequencing. This method adapted techniques commonly known in oncology, specifically circulating tumor DNA (ctDNA) analysis, to examine cell-free DNA (cfDNA) present in patient samples like blood. Analyzing cfDNA allows researchers to look for viral DNA fragments. The significant advantage of this approach is its potential speed and scalability; detecting a high fraction of a specific variant's signature within the circulating viral DNA pool provides a valuable population-level marker, especially useful when resources for intensive, sample-by-sample whole-genome sequencing are constrained, offering a crucial second opinion on community prevalence.

What non-genetic surveillance method adapts oncology analysis for viral DNA fragments?

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